An Improved Method for P2X7R Antagonist Screening
نویسندگان
چکیده
منابع مشابه
An Improved Method for P2X7R Antagonist Screening
ATP physiologically activates the P2X7 receptor (P2X7R), a member of the P2X ionotropic receptor family. When activated by high concentrations of ATP (i.e., at inflammation sites), this receptor is capable of forming a pore that allows molecules of up to 900 Da to pass through. This receptor is upregulated in several diseases, particularly leukemia, rheumatoid arthritis and Alzheimer's disease....
متن کاملCorrection: An Improved Method for P2X7R Antagonist Screening
There are errors in the seventh sentence of the Abstract. Specifically, the values provided for ATP, BBG and OATP are incorrect. The correct sentence is: The values obtained were consistent with those found in the literature (0.7 ± 0.07 mM, 1.3–2.6 μM and 173–285 μM for ATP, BBG and OATP, respectively). Additionally, there are errors in the units of Table 1. The correct units for columns BBG (I...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0123089